PTPN1 Antibody | XW-7826

PTPN1 Antibody | XW-7826 | Gentaur UK, US & Europe Distribution

Host: Chicken

Reactivity: Human, Rat

Homology: N/A

Immunogen: 288-364

Research Area: Signal Transduction

Tested Application: WB

Application: Tyrosine-protein phosphatase non-receptor type 1 antibody can be used for the detection of Tyrosine-protein phosphatase non-receptor type 1 by Western Blot.

Specificiy: N/A

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: 50 kDa (calculated)

Validation: N/A

Isoform: N/A

Purification: Immunoaffinity Purified

Clonality: Polyclonal

Clone: N/A

Isotype: N/A

Conjugate: Unconjugated

Physical State: Liquid

Buffer: Phosphate-Buffered Saline. No preservatives added.

Concentration: 1 mg/mL

Storage Condition: PTPN1 antibody can be stored at 4˚C for short term (weeks) . Long term storage should be at -20˚C. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Alternate Name: PTP1B, Tyrosine-protein phosphatase non-receptor type 1, Protein-tyrosine phosphatase 1B, PTP-1B, PTP1B, Tyrosineprotein phosphatase nonreceptor type 1

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: FUNCTION: May play an important role in CKII- and p60c-src-induced signal transduction cascades (By similarity) .

CATALYTIC ACTIVITY: Protein tyrosine phosphate + H₂O = protein tyrosine + phosphate.

PTM: Oxidized on Cys-215; the Cys-SOH formed in response to redox signaling reacts with the α-amido of the following residue to form a 4-amino-3-isothiazolidinone serine cross-link, triggering a conformational change that inhibits substrate binding and activity. The active site can be restored by reduction.