PTPRN Antibody (Center) [AMR09655G]

PTPRN Antibody (Center) [AMR09655G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This PTPRN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 288-316 amino acids from the Central region of human PTPRN.

Cellular Localisation: Membrane {ECO:0000250|UniProtKB:Q63259}; Single- pass type I membrane protein {ECO:0000250|UniProtKB:Q63259} Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type I membrane protein. Perikaryon {ECO:0000250|UniProtKB:Q63259}. Cell projection, axon {ECO:0000250|UniProtKB:Q63259}. Cell junction, synapse {ECO:0000250|UniProtKB:Q63259}. Cell membrane; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q63259}. Endosome {ECO:0000250|UniProtKB:Q63259}. Note=Detected on neuronal secretory vesicles, but not on synaptic vesicles. Colocalizes with insulin- containing secretory granules (PubMed:25561468) . Primarily detected on secretory vesicle membranes. Transiently found at the cell membrane, when secretory vesicles fuse with the cell membrane to release their cargo. Is then endocytosed and recycled to secretory vesicles via the Golgi apparatus membranes. {ECO:0000250|UniProtKB:Q63259, ECO:0000269|PubMed:25561468} [ICA512-cleaved cytosolic fragment]: Nucleus

Molecular Weight: 105848

Clone: Polyclonal

Gene Name: PTPRN

Gene ID: 5798

Function: Plays a role in vesicle-mediated secretory processes (PubMed:24843546) . Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets (By similarity) . Required for the accumulation of normal levels of insulin- containing vesicles and preventing their degradation (PubMed:24843546) . Plays a role in insulin secretion in response to glucose stimuli (PubMed:24843546) . Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain (By similarity) . In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (By similarity) . Required to maintain normal levels of renin expression and renin release (By similarity) . Seems to lack intrinsic enzyme activity (By similarity) . May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (By similarity) .

Summary: Tissue Location: Expression is restricted to neuroendocrine cells. Found in pancreas, brain and pituitary.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Receptor-type tyrosine-protein phosphatase-like N, R-PTP-N, Islet cell antigen 512, ICA 512, Islet cell autoantigen 3, PTP IA-2, PTPRN, ICA3, ICA512