PTPRZ1 Antibody (N-term) [APR13029G]

PTPRZ1 Antibody (N-term) [APR13029G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This PTPRZ1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 446-480 amino acids from the N-terminal region of human PTPRZ1.

Cellular Localisation: [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Secreted. Note=A secreted form is apparently generated by shedding of the extracellular domain

Molecular Weight: 254587

Clone: Polyclonal

Gene Name: PTPRZ1

Gene ID: 5803

Function: Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades (By similarity) .

Summary: Tissue Location: Specifically expressed in the central nervous system, where it is localized in the Purkinje cell layer of the cerebellum, the dentate gyrus, and the subependymal layer of the anterior horn of the lateral ventricle. Developmentally regulated in the brain.

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Receptor-type tyrosine-protein phosphatase zeta, R-PTP-zeta, Protein-tyrosine phosphatase receptor type Z polypeptide 1, Protein-tyrosine phosphatase receptor type Z polypeptide 2, R-PTP-zeta-2, PTPRZ1, HTPZP2, PTPRZ, PTPRZ2, PTPZ