Pumilio 1 polyclonal Antibody | BS91138

Pumilio 1 polyclonal Antibody | BS91138 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse

Application: WB ICC IF IHC FC IP

Application Range: WB:1:1,000-1:2,000 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100 IP:1:10-1:50

Background: Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) . Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation. Also mediates deadenylation-independent repression by promoting accessibility of miRNAs.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Specificity: Pumilio 1 polyclonal Antibody detects endogenous levels of Pumilio 1 protein.

Molecular Weight: 126 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: HsPUM, Pumilio-1, PUM1, KIAA0099, PUMH1, HsPUM, KIAA0099, PUM 1, PUM L1, Pum1, PUM1, PUMH 1, PUMH, PUMH1, pumilio homolog 1 (Drosophila), Pumilio homolog 1, Pumilio-1, Pumilio1, PUML 1, PUML1,

Immunogen: Recombinant protein within human Pumilio 1 aa 1-200.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: