PURB Antibody (C-term) [AMM22309G]

PURB Antibody (C-term) [AMM22309G] | Gentaur UK, US & Europe Distribution

Product Category: Monoclonal Antibodies

Host: Mouse

Species Reactivity: H, M

Specificity: This PURB antibody is generated from a mouse immunized with a recombiant protein of human PURB.

Cellular Localisation: Nucleus.

Molecular Weight: 33241

Clone: Monoclonal

Gene Name: PURB

Gene ID: 5814

Function: Has capacity to bind repeated elements in single-stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene. Plays a role in the control of vascular smooth muscle (VSM) alpha-actin gene transcription as repressor in myoblasts and fibroblasts. Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine-rich negative regulatory (PNR) element. Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. May play a role in the dendritic transport of a subset of mRNAs (By similarity) .

Summary: Tissue Location: Expressed in myocardium of heart failure patients.

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:8000

Synonyms: Transcriptional activator protein Pur-beta, Purine-rich element-binding protein B, PURB