Purified Anti-Human CD279/PD-1 Monoclonal Antibody | DL22250F

Purified Anti-Human CD279/PD-1 Monoclonal Antibody | DL22250F | Gentaur UK, US & Europe Distribution

Host: Mouse

Synonyms: PDCD1, PD1, Protein PD-1, hPD-1

Reactivity: Human

Application: FCM, IHC

Background: Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 and PD-L2 are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion.

Concentration: 0.2 mg/mL

Conjugation: Unconjugated

Buffer: PBS with 0.05% Proclin300

Clone: J110

Isotype: Mouse IgG1, κ