Purified Anti-Mouse CD272 Antibody[PK18.6] | E-AB-F1024A

Purified Anti-Mouse CD272 Antibody[PK18.6] | E-AB-F1024A | Gentaur UK, US & Europe Distribution

Category: Flowcytometry Antibody

Synonyms: B- and T-lymphocyte attenuator,Btla,B- and T-lymphocyte-associated protein,CD272,Btla

Swissprot Code: Q7TSA3

Application: FCM,IP

Reactivity: Mouse

Host: Rat

Isotype: Rat IgG2a, κ

Research Areas: Immunology

Backgroun: CD272, also known as B and T lymphocyte attenuator (BTLA), is an Ig superfamily co-inhitory receptor with structural similarity to programmed cell death 1 (PD-1) and CTLA-4. BTLA is expressed on B cells, T cells, macrophages, dendritic cells, NKT cells, and NK cells. Engagement of BTLA by its ligand herpes virus entry mediator (HVEM) is critical for negatively regulating immune response. The absence of BTLA with HVEM inhibitory interactions leads to increased experimental autoimmune encephalomyelitis severity, enhanced rejection of partially mismatched allografts, an increased CD8+ memory T cell population, increased severity of colitis, and reduced effectiveness of T regulatory cells. BTLA plays an important role in the induction of peripheral tolerance of both CD4+ and CD8+ T cells in vivo. Tolerant T cells have significantly higher expression of BTLA compared with effectors and nave T cells. BTLA may cooperate with CTLA-4 and PD-1 to control T cell tolerance and autoimmunity. It was reported that BTLA may regulate T cell function by binding to B7-H4, but further studies are needed to confirm. The existence of three distinct BTLA alleles has been reported.

Concentration: 0.5 mg/mL

Storage: Store at 2~8°C. Do not freeze.

Immunogen: N/A

Buffer: PBS with 0.05% Proclin300

Purification Method: N/A

Dilution: N/A

Clone: PK18.6

Conjugation: Unconjugated

Moleculair Weight(Calculated): N/A

Moleculair Weight(Observed): N/A