PX 12 | 2217

PX-12 is an irreversible inhibitor of thioredoxin-1 (TRX-1) (Ki = 31 µM). It decreases the expression of HIF-1α, VEGF and iNOS (IC₅₀ values are 7.2, ~10 and 18.1 μM respectively). Also known to display antitumor activity and inhibits tubulin polymerization in vitro.

PX-12 is an irreversible inhibitor of thioredoxin-1 (TRX-1) (Ki = 31 µM). It decreases the expression of HIF-1α, VEGF and iNOS (IC₅₀ values are 7.2, ~10 and 18.1 μM respectively). Also known to display antitumor activity and inhibits tubulin polymerization in vitro.

2217 | PX 12 DataSheet

Alternate Name/Synonyms: 2-[(1-Methylpropyl)dithio]-1H-imidazole; IV-2

Appearance: Beige solid

Formulation: N/A

CAS Number: 141400-58-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₇H₁₂N₂S₂

Molecular Weight: 188.31

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (100 mM)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: An irreversible inhibitor of thioredoxin-1 (TRX-1)

MDL Number: MFCD18086851

PubChem CID: 219104

SMILES: CCC(C)SSC1=NC=CN1

InChi: InChI=1S/C7H12N2S2/c1-3-6(2)10-11-7-8-4-5-9-7/h4-6H,3H2,1-2H3,(H,8,9)

InChi Key: BPBPYQWMFCTCNG-UHFFFAOYSA-N