PYR-41 | 1925

Cell-permeable. An irreversible ubiquitin-activating enzyme (E1) inhibitor (IC₅₀ < 10 μM). Blocks ubiquitylation and prevents ubiquitin-mediated proteasomal degradation. Inhibits NF-κB activation, blocks degradation of p53, increases p21 levels and induces apoptosis in vitro. Also causes an increase in sumoylation of proteins.

PYR-41 is an irreversible ubiquitin-activating enzyme (E1) inhibitor (IC₅₀ < 10 μM). Blocks ubiquitylation and prevents ubiquitin-mediated proteasomal degradation. Inhibits NF-κB activation, blocks degradation of p53, increases p21 levels and induces apoptosis in vitro. Also causes an increase in sumoylation of proteins.

1925 | PYR-41 DataSheet

Alternate Name/Synonyms: 4-[4-[(5-Nitro-2-furanyl)methylene]-3,5-dioxo-1-pyrazolidinyl]benzoic acid ethyl ester

Appearance: Brown solid

Formulation: N/A

CAS Number: 418805-02-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₇H₁₃N₃O₇

Molecular Weight: 371.3

Cell-Permeable?: Yes

Purity: ≥98% by TLC

Solubilities: DMSO (~25 mg/ml)

Handling: Protect from light and air

Country of Origin: USA

Tag Line: An irreversible ubiquitin-activating enzyme (E1) inhibitor

MDL Number: N/A

PubChem CID: 5335621

SMILES: CCOC(=O)C1=CC=C(C=C1)N2C(=O)C(=CC3=CC=C(O3)[N+](=O)[O-])C(=O)N2

InChi: InChI=1S/C17H13N3O7/c1-2-26-17(23)10-3-5-11(6-4-10)19-16(22)13(15(21)18-19)9-12-7-8-14(27-12)20(24)25/h3-9H,2H2,1H3,(H,18,21)/b13-9-

InChi Key: ARGIPZKQJGFSGQ-LCYFTJDESA-N