Pyrimethamine | B3264

Pyrimethamine is an antiprotozoal agent that inhibits the protozoal enzyme dihydrofolate reductase (DHFR). By blocking DHFR activity, pyrimethamine prevents the production of tetrahydrofolic acid, an essential coenzyme involved in DNA and RNA synthesis. In in vivo antimalarial mouse models, pyrimethamine displays a prophylactic effect at an ED50 value of 0.5 mg/kg.

Pyrimethamine is an antiprotozoal agent that inhibits the protozoal enzyme dihydrofolate reductase (DHFR). By blocking DHFR activity, pyrimethamine prevents the production of tetrahydrofolic acid, an essential coenzyme involved in DNA and RNA synthesis. In in vivo antimalarial mouse models, pyrimethamine displays a prophylactic effect at an ED50 value of 0.5 mg/kg.

B3264 | Pyrimethamine DataSheet

Alternate Name/Synonyms: NSC3061 5,4-chlorophenyl-6-ethyl-2,4-pyrimidinediamine Darapram

Appearance: White to off-white solid

Formulation:

CAS Number: 58-14-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₂H₁₃ClN₄

Molecular Weight: 248.71

Cell-Permeable?: True

Purity: ≥98%

Solubilities:

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An antiprotozoal agent

MDL Number: MFCD00057350

PubChem CID: 4993

SMILES: ClC1=CC=C(C2=C(CC)N=C(N)N=C2N)C=C1

InChi: InChI=1S/C12H13ClN4/c1-2-9-10(11(14)17-12(15)16-9)7-3-5-8(13)6-4-7/h3-6H,2H2,1H3,(H4,14,15,16,17)

InChi Key: WKSAUQYGYAYLPV-UHFFFAOYSA-N