PZ-2891 | B2460

PZ-2891 (PZ2891) a specific, allosteric, brain-permeable, pantothenate kinase (PANK) modulator. it acts as both an orthosteric inhibitor (IC₅₀ =1.3 nM, hPANK3) and an allosteric activator of PANK3 activity in the presence of acetyl-CoA in biochemical assays.

Z-2891 (PZ2891) a specific, allosteric, brain-permeable, pantothenate kinase (PANK) modulator. it acts as both an orthosteric inhibitor (IC₅₀ =1.3 nM, hPANK3) and an allosteric activator of PANK3 activity in the presence of acetyl-CoA in biochemical assays.

B2460 | PZ-2891 DataSheet

Alternate Name/Synonyms: PZ2891; 6-(4-(2-(4-isopropylphenyl)acetyl)piperazin-1-yl)pyridazine-3-carbonitrile

Appearance: Crystalline solid

Formulation:

CAS Number: 2170608-82-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₂₃N₅O

Molecular Weight: 349.44

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent and selective, orally active Pantothenate kinase (PANK) modulator

MDL Number:

PubChem CID: N/A

SMILES: N#CC1=NN=C(N2CCN(C(CC3=CC=C(C(C)C)C=C3)=O)CC2)C=C1

InChi: InChI=1S/C20H23N5O/c1-15(2)17-5-3-16(4-6-17)13-20(26)25-11-9-24(10-12-25)19-8-7-18(14-21)22-23-19/h3-8,15H,9-13H2,1-2H3

InChi Key: LGWDVWIZDPGCFG-UHFFFAOYSA-N