QDPR polyclonal Antibody | BS7822

QDPR polyclonal Antibody | BS7822 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IF

Application Range: WB: 1:500~1:2000 IF: 1:50~1:200

Background: QDPR (quinoid dihydropteridine reductase), also known as DHPR (dihydropteridine reductasae) or PKU2, is a member of the short-chain dehydrogenases/reductase (SDR) family of enzymes. Functioning as a homodimer, QDPR plays an important role in the recycling of tetrahydrobiopterin (BH4), an essential cofactor for the hydroxylation of the aromatic amino acids (tryptophan, tyrosine and phenylalanine) . More specifically, QDPR catalyzes the regeneration of BH4 from quinonoid dihydrobiopterin (qBH2), the product generated from the hydroxylation reactions. Mutations in the gene encoding QDPR can lead to phenylketonuria II (also called PK2 or dihydropteridine reductase deficiency), a disorder resulting from the depletion of dopamine, epinephrine and serotonin due to defective recycling of BH4. Symptoms of PK2 include hyperphenylalaninemia, axial hypotonia, truncal hypertonia, microcephaly and abnormal thermogenesis.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: QDPR polyclonal Antibody detects endogenous levels of QDPR protein.

Molecular Weight: ~ 26 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: DHPR_HUMAN; Dihydropteridine reductase; HDHPR; HPR; Qdpr; Quinoid dihydropteridine reductase;

Immunogen: Recombinant full length Human QDPR.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Adherens Junction signaling,