QKI Antibody (N-term) [APR13034G]

QKI Antibody (N-term) [APR13034G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This QKI antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human QKI.

Cellular Localisation: Nucleus. Cytoplasm.

Molecular Weight: 37671

Clone: Polyclonal

Gene Name: QKI

Gene ID: 9444

Function: RNA-binding protein that plays a central role in myelinization (PubMed:16641098) . Binds to the 5'-NACUAAY-N (1, 20) -UAAY- 3' RNA core sequence. Regulates target mRNA stability (PubMed:23630077) . In addition, acts by regulating pre-mRNA splicing, mRNA export and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia (PubMed:16641098) . Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity) .

Summary: Tissue Location: Expressed in the frontal cortex of brain. Down- regulated in the brain of schizophrenic patients

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: IHC-P, WB

Dilution: IHC-P--1:100 WB--1:2000

Synonyms: Protein quaking, Hqk, HqkI, QKI, HKQ