R Cask Antibody (Center) [APR13040G]

R Cask Antibody (Center) [APR13040G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: Rat

Specificity: This Rat Cask antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 589-616 amino acids from the Central region of rat Cask.

Cellular Localisation: Nucleus. Cytoplasm. Cell membrane; Peripheral membrane protein

Molecular Weight: 103259

Clone: Polyclonal

Gene Name: Cask

Gene ID: 29647

Function: Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins, and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity) .

Summary: Tissue Location: Expressed in the foot process layer of podocytes in the kidney glomerulus and in tubules (at protein level) . Detected in brain and neurons.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Peripheral plasma membrane protein CASK, Calcium/calmodulin-dependent serine protein kinase, Cask