R112 | B2913

R112 is an inhibitor of spleen tyrosine kinase (Syk) with an IC₅₀ of 226 nM in cultured human mast cells. It is an ATP-competitive Syk inhibitor with a Ki of 96 nM. It completely and rapidly inhibits all mast cell activation cascades triggered by IgE receptor cross-linking: degranulation, lipid mediator production, and cytokine production.

R112 is an inhibitor of spleen tyrosine kinase (Syk) with an IC₅₀ of 226 nM in cultured human mast cells. It is an ATP-competitive Syk inhibitor with a Ki of 96 nM. It completely and rapidly inhibits all mast cell activation cascades triggered by IgE receptor cross-linking: degranulation, lipid mediator production, and cytokine production.

B2913 | R112 DataSheet

Alternate Name/Synonyms: 3-[[5-fluoro-2-(3-hydroxyanilino)pyrimidin-4-yl]amino]phenol; (E)-Elafibranor; 3,3'-(5-fluoropyrimidine-2,4-diyl)bis(azanediyl)diphenol; N2,N4-bis(3-hydroxyphenyl)-5-fluoro-2,4-primidinediamine; 3,3'-[(5-fluoro-2,4-pyrimidinediyl)diimino]bis-phenol

Appearance: A crystalline solid

Formulation:

CAS Number: 575474-82-7

Structure Available?: True

Peptide sequence:

Salt Form: false

Molecular Formula: C₁₆H₁₃FN₄O₂

Molecular Weight: 312.3

Cell-Permeable?: True

Purity: > 98%

Solubilities: ~30 mg/ml in in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inhibitor of spleen tyrosine kinase (Syk)

MDL Number:

PubChem CID: 9904854

SMILES: C1=CC(=CC(=C1)O)NC2=NC(=NC=C2F)NC3=CC(=CC=C3)O

InChi: InChI=1S/C16H13FN4O2/c17-14-9-18-16(20-11-4-2-6-13(23)8-11)21-15(14)19-10-3-1-5-12(22)7-10/h1-9,22-23H,(H2,18,19,20,21)

InChi Key: