RAB7L1 Antibody [AMM22256G]

RAB7L1 Antibody [AMM22256G] | Gentaur UK, US & Europe Distribution

Product Category: Monoclonal Antibodies

Host: Mouse

Species Reactivity: H

Specificity: This RAB7L1 antibody is generated from a mouse immunized with a recombinant protein of human RAB7L1.

Cellular Localisation: Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus. Golgi apparatus, trans-Golgi network. Vacuole. Cytoplasm, cytoskeleton. Note=Colocalizes with LRRK2 along tubular structures emerging from Golgi apparatus (PubMed:29212815) Colocalizes with GM130 at the Golgi apparatus (PubMed:22042847) Colocalizes with dynamic tubules emerging from and retracting to the Golgi apparatus (PubMed:22042847) . Colocalizes with TGN46 at the trans- Golgi network (TGN) (PubMed:24788816) . In Salmonella enterica serovar Typhi (S.Typhi) infected epithelial cells, is recruited and colocalized with both S.Typhi-containing vacuoles and dynamic tubules as well as those emerging from the vacuole toward the cell periphery (PubMed:22042847) .

Molecular Weight: 23155

Clone: Monoclonal

Gene Name: RAB29

Gene ID: 8934

Function: The small GTPases Rab are key regulators in vesicle trafficking (PubMed:24788816) . Essential for maintaining the integrity of the endosome-trans-Golgi network structure (By similarity) . Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:24788816) . Recruits LRRK2 to the Golgi complex and stimulates LRRK2 kinase activity (PubMed:29212815) . Regulates neuronal process morphology in the intact central nervous system (CNS) (By similarity) . May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.Typhi) epithelial cell infection (PubMed:22042847) .

Summary: Tissue Location: Ubiquitous..

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000-1:2000

Synonyms: Ras-related protein Rab-7L1, Rab-7-like protein 1, Ras-related protein Rab-29, RAB29, RAB7L1