Rabbit Anti-Human Endostatin Antibody | 102-P226

Rabbit Anti-Human Endostatin Antibody | 102-P226 | Gentaur UK, US & Europe Distribution

Species: Anti-Human

Host / biotech: Rabbit

Comment: N/A

Label: N/A

Clone / Antibody feature: Rabbit IgG

Subcategory: Polyclonal Antibody

Category: Antibody

Synonyms: COL18A1; KS; KNO; KNO1

Isotype: N/A

Application: ELISA, WB

Detection Range: N/A

Species Reactivity/Cross reactivity: Human

Antigen: Recombinant Human Endostatin

Description: Endostatin, an endogenous non-glycosylated inhibitor of endothelial cell proliferation and angiogenesis, is an approximately 181 amino acid (aa), 20 kDa proteolytic fragment of the C-terminal non collagenous domain of type XVIII collagen. It is produced and/or trimmed by metalloproteinases such as MMP2 and MMP9, and cathepsins S, B and L. The Nterminal ~27 aa of Endostatin appear to contain the majority of its activity. This region contains three zinc binding sites that are thought to be critical for its anti-endothelial and ant-itumor effects, as well as multiple cleavage sites that, when used, can modify its activity. Human Endostatin shares 84-87% aa sequence identity with mouse, rat, bovine and equine Endostatin. Endostatin inhibits endothelial cell growth by inducing cell cycle arrest in G1 phase and initiating apoptosis. It is also thought to downregulate angiogenesis by blocking VEGF-induced endothelial cell migration. It alters the effect of FGF basic on adhesion and cell motility. Endostatin can interact with Transglutaminase 2, heparin, and integrins α5β1 and αv β3, all of which may be secreted by, or expressed on, endothelial cells, and can influence adhesion or migration.

Purity Confirmation: N/A

Endotoxin: N/A

Formulation: lyophilized from PBS

Storage Handling Stability: The lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.

Reconstituation: Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.

Molecular Weight: N/A

Lenght (aa): N/A

Protein Sequence: N/A

NCBI Gene ID: 80781