Description
RAC1 Antibody | XW-7987 | Gentaur UK, US & Europe Distribution
Host: Chicken
Reactivity: Human, Mouse, Bovine
Homology: N/A
Immunogen: 1-192
Research Area: Homeostasis
Tested Application: WB
Application: RAC1 antibody can be used for the detection of Ras-related C3 botulinum toxin substrate 1 by Western Blot.
Specificiy: N/A
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: 21.5 kDa (calculated)
Validation: N/A
Isoform: N/A
Purification: Immunoaffinity Purified
Clonality: Polyclonal
Clone: N/A
Isotype: N/A
Conjugate: Unconjugated
Physical State: Liquid
Buffer: Phosphate-Buffered Saline. No preservatives added.
Concentration: 1 mg/mL
Storage Condition: RAC1 antibody can be stored at 4˚C for short term (weeks) . Long term storage should be at -20˚C. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Alternate Name: TC25, MIG5, Ras-related C3 botulinum toxin substrate 1, Cell migration-inducing gene 5 protein, Rasrelated C3 botulinum toxin substrate 1, p21-Rac1, Ras-like protein TC25
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: FUNCTION: Isoform B has an accelerated GEF-independent GDP/GTP exchange and an impaired GTP hydrolysis, which is restored partially by GTPase-activating proteins. It is able to bind to the GTPase-binding domain of PAK but not full-length PAK in a GTP-dependent manner, suggesting that the insertion does not completely abolish effector interaction.
SUBUNIT: Interacts with the GEF proteins PREX1, DOCK1 and DOCK2, which promote the exchange between GDP and GTP, and therefore activate it. Interacts with PARD6A, PARD6B and PARD6G in a GTP-dependent manner. Part of a quaternary complex containing PARD3, some PARD6 protein (PARD6A, PARD6B or PARD6G) and some atypical PKC protein (PRKCI or PRKCZ) , which plays a central role in epithelial cell polarization. Found in a trimeric complex composed of DOCK1 and ELMO1, which plays a central role in phagocytosis of apoptotic cells. Interacts with RALBP1 via its effector domain. Interacts with PLXNB1. Part of a complex with MAP2K3, MAP3K3 and CCM2 (By similarity) . Interacts with BAIAP2.
SUMMARY: