RAC1 Antibody | XW-7987

RAC1 Antibody | XW-7987 | Gentaur UK, US & Europe Distribution

Host: Chicken

Reactivity: Human, Mouse, Bovine

Homology: N/A

Immunogen: 1-192

Research Area: Homeostasis

Tested Application: WB

Application: RAC1 antibody can be used for the detection of Ras-related C3 botulinum toxin substrate 1 by Western Blot.

Specificiy: N/A

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: 21.5 kDa (calculated)

Validation: N/A

Isoform: N/A

Purification: Immunoaffinity Purified

Clonality: Polyclonal

Clone: N/A

Isotype: N/A

Conjugate: Unconjugated

Physical State: Liquid

Buffer: Phosphate-Buffered Saline. No preservatives added.

Concentration: 1 mg/mL

Storage Condition: RAC1 antibody can be stored at 4˚C for short term (weeks) . Long term storage should be at -20˚C. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Alternate Name: TC25, MIG5, Ras-related C3 botulinum toxin substrate 1, Cell migration-inducing gene 5 protein, Rasrelated C3 botulinum toxin substrate 1, p21-Rac1, Ras-like protein TC25

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: FUNCTION: Isoform B has an accelerated GEF-independent GDP/GTP exchange and an impaired GTP hydrolysis, which is restored partially by GTPase-activating proteins. It is able to bind to the GTPase-binding domain of PAK but not full-length PAK in a GTP-dependent manner, suggesting that the insertion does not completely abolish effector interaction.
SUBUNIT: Interacts with the GEF proteins PREX1, DOCK1 and DOCK2, which promote the exchange between GDP and GTP, and therefore activate it. Interacts with PARD6A, PARD6B and PARD6G in a GTP-dependent manner. Part of a quaternary complex containing PARD3, some PARD6 protein (PARD6A, PARD6B or PARD6G) and some atypical PKC protein (PRKCI or PRKCZ) , which plays a central role in epithelial cell polarization. Found in a trimeric complex composed of DOCK1 and ELMO1, which plays a central role in phagocytosis of apoptotic cells. Interacts with RALBP1 via its effector domain. Interacts with PLXNB1. Part of a complex with MAP2K3, MAP3K3 and CCM2 (By similarity) . Interacts with BAIAP2.
SUMMARY: