RAC1 monoclonal Antibody | LM2177

RAC1 monoclonal Antibody | LM2177 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human,Rat

Application: WB IHC-P FC

Application Range: WB: 1:500~1000 IHC: 1:10~50 FCM: 1:100

Background: Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. In glioma cells, promotes cell migration and invasion. In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: RAC1 monoclonal Antibody detects endogenous levels of RAC1 protein.

Molecular Weight: ~ 23 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Ras-related C3 botulinum toxin substrate 1; Cell migration-inducing gene 5 protein; Ras-like protein TC25; p21-Rac1; RAC1; TC25; MIG5

Immunogen: This Antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between amino acids from human.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Purified Antibody in PBS with 0.05% sodium azide and 0.5% protein stabilizer

Pathway: