RAD51 Antibody | 22-093

RAD51 Antibody | 22-093 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 50-150 of human RAD51 (NP_002866.2) .

Research Area: Cell Cycle

Tested Application: WB

Application: WB: 1:500 - 1:1000

Specificiy: N/A

Positive Control 1: U-937

Positive Control 2: Mouse brain

Positive Control 3: Mouse ovary

Positive Control 4: Mouse testis

Positive Control 5: Rat testis

Positive Control 6: N/A

Molecular Weight: Observed: 37kDa

Validation: N/A

Isoform: N/A

Purification: Affinity purification

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Concentration: N/A

Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.

Alternate Name: RAD51A, RECA, DNA repair protein RAD51 homolog 1, RAD51 homolog A, HsRAD51, BRCC5, MRMV2, HRAD51, HsRad51, HsT16930

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene.