Radicicol | B1533

Radicicol is an antifungal antibiotic that inhibits heat shock protein 90 (Hsp90) activity by binding to the ATP-binding pocket, subsequently suppressing cell transformation induced by src, ras and mos. Represses estrogen receptor transcriptional activity and inhibits angiogenesis. Radicicol also binds to and inhibits DNA topoisomerase type II proteins and GRP94 through an ATPase domain common to Hsp90.

Radicicol is an antifungal antibiotic that inhibits heat shock protein 90 (Hsp90) activity by binding to the ATP-binding pocket, subsequently suppressing cell transformation induced by src, ras and mos. Represses estrogen receptor transcriptional activity and inhibits angiogenesis. Radicicol also binds to and inhibits DNA topoisomerase type II proteins and GRP94 through an ATPase domain common to Hsp90.

B1533 | Radicicol DataSheet

Alternate Name/Synonyms: KF9-A, KF58332, Monorden, NSC 294404

Appearance: White solid

Formulation: N/A

CAS Number: 12772-57-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₁₈H₁₇ClO₆

Molecular Weight: 364.78

Cell-Permeable?: Yes

Purity: ≥98%

Solubilities: DMSO (>20 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: An antifungal antibiotic and heat shock protein 90 (Hsp90) inhibitor

MDL Number: MFCD06795865

PubChem CID: 6323491

SMILES: CC1CC2C(O2)C=CC=CC(=O)CC3=C(C(=CC(=C3Cl)O)O)C(=O)O1

InChi: InChI=1S/C18H17ClO6/c1-9-6-15-14(25-15)5-3-2-4-10(20)7-11-16(18(23)24-9)12(21)8-13(22)17(11)19/h2-5,8-9,14-15,21-22H,6-7H2,1H3/b4-2+,5-3-/t9-,14-,15-/m1/s1

InChi Key: WYZWZEOGROVVHK-GTMNPGAYSA-N