RAP1GAP Antibody | 13-708

RAP1GAP Antibody | 13-708 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Homology: N/A

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 508-727 of human RAP1GAP (NP_001139130.1) .

Research Area: Cancer, Signal Transduction

Tested Application: WB

Application: WB: 1:1000 - 1:2000

Specificiy: N/A

Positive Control 1: U-87MG

Positive Control 2: 293T

Positive Control 3: SGC-7901

Positive Control 4: LO2

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Observed: 90kDa

Validation: N/A

Isoform: N/A

Purification: Affinity purification

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Concentration: N/A

Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.

Alternate Name: RAP1GA11, RAP1GAPII, RAPGAP, RAP1GAP, rap1 GTPase-activating protein 1

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs) , act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins.