BW
RAPGEF3 polyclonal Antibody | BS5713
- SKU:
- BW-BS5713
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- Usually ships in 5 working days
Description
RAPGEF3 polyclonal Antibody | BS5713 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: WB ICC
Application Range: WB: 1:500~1:1000 ICC: 1:50~1:200
Background: 3',5' cyclic adenosine monophosphate (cAMP) -regulated guanine nucleotide exchange factors Epac (Epac1, cAMP-GEFI) and Epac2 (cAMP-GEFII) activate the Ras family GTPases Rap 1 and Rap 2 by promoting GTP binding in a cAMP-dependent manner. Eukaryotic cAMP is a second messenger that induces physiological responses such as gene expression, growth, differentiation, secretion and neurotransmission. The human Epac gene maps to chromosome 12q13.11 with transcript being abundant in the kidney and heart. In situ hybridization indicates expression of Epac in adult rat brain and selective expression in neonatal brain, including septum and thalamus.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: RAPGEF3 polyclonal Antibody detects endogenous levels of RAPGEF3 protein.
Molecular Weight: ~ 99 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Rap guanine nucleotide exchange factor 3; Exchange factor directly activated by cAMP 1; Exchange protein directly activated by cAMP 1; EPAC 1; Rap1 guanine-nucleotide-exchange factor directly activated by cAMP; cAMP-regulated guanine nucleotide exchange factor I; cAMP-GEFI; CGEF1; EPAC; EPAC1
Immunogen: Synthetic peptide, corresponding to amino acids 799-844 of Human RAPGEF3.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: