Description
RAPSN polyclonal Antibody | BS8379 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: WB IHC
Application Range: WB: 1:500~1:2000 IHC: 1:50~1:200
Background: The RAPSN gene locus is located on chromosome 11p11.1-p11.2 and encodes a peripheral membrane protein. Rapsyn (receptor-associated protein of the synapse) is expressed in the postsynaptic membrane of skeletal muscle. Rap-syn is required for the clustering of nicotinic acetylcholine receptors (nAChR) . Rapsyn self-associates through at least two of its seven tetra-tricopeptide repeats (TPRs) . Rapsyn interacts with the large intracellular domain of the nAChR a subunit through the hydrophobic surface of the coiled-coil domain. Rapsyn modifies trafficking of AChR within the cell. Expression is essential for agrin-induced AChR clustering. Overexpression inhibits agrin-induced AChR clustering pathway. Absence of rapsyn causes deficit in the formation of postsynaptic specializations at neuromuscular synapse, which increases axonal branching and motonueron survival. Rapsyn plays a role in selective targeting of newly synthesized intracellular AChR to postsynaptic membrane.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: RAPSN polyclonal Antibody detects endogenous levels of RAPSN protein.
Molecular Weight: ~ 46 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: 43 kDa receptor-associated protein of the synapse; RAPsyn; 43 kDa postsynaptic protein; Acetylcholine receptor-associated 43 kDa protein; RING finger protein 205; RAPSN; RNF205
Immunogen: Recombinant full length Human RAPSN.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: