Ras polyclonal Antibody | BS91158

Ras polyclonal Antibody | BS91158 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat, zebrafish

Application: WB ICC/IF IP

Application Range: WB:1:1,000-1:2,000 ICC:1:100-1:500

Background: The mammalian c-H-, c-K- and N-Ras proto-oncogenes encode guanine nucleotide-binding proteins that are ubiquitously expressed in vertebrate cells. c-H- and c-K-Ras are cellular homologs of the v-H and v-K-Ras sequences originally isolated from the Harvey and Kirsten strains of rat sarcoma virus. Ras-encoded proteins bind GDP and GTP with high affinity and possess a low level intrinsic GTPase activity that can be stimulated over 100-fold by interaction with cytosolic GTPase activating protein (GAP), a potential effector for Ras p21 function. Point mutations at amino acids 12, 13, 59 and 61 within domains responsible for GTP binding and hydrolysis activate Ras proteins to their oncogenic form and block the ability of the GTPase activity to be stimulated by GAP. Several additional proteins with GAP activity have been identified and shown to interact with p21 Ras or other members of the Ras gene family.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: Ras polyclonal Antibody detects endogenous levels of Ras protein.

Molecular Weight: 21 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: NRAS, HRAS, KRAS, C-BAS/HAS, c-H-ras, C-HA-RAS1, CTLO, GTPase HRas, GTPase KRas, GTPase NRas, H-Ras-1, H-RASIDX, Ha-Ras, HAMSV, HRAS, HRAS1, K RAS2A, K RAS2B, K RAS4A, K RAS4B, K-RAS, KRAS, KRAS1, KRAS2, N-RAS, N-terminally processed, NRAS, NRAS1, p21ras, RASH, RASH1, RASK2, Transforming protein p21, v Ha ras Harvey rat sarcoma viral oncogene homolog, v Ki ras2 Kirsten rat sarcoma viral oncogene homolog, v ras neuroblastoma RAS viral oncogene homolog,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: