RASSF1 polyclonal Antibody | BS6244

RASSF1 polyclonal Antibody | BS6244 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse

Application: WB IF

Application Range: WB: 1:500~1:2000 IF: 1:50~1:200

Background: Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: RASSF1 polyclonal Antibody detects endogenous levels of RASSF1 protein.

Molecular Weight: ~ 39 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: 123F2; Cardiac specific ras association domain family 1 protein; NORE2A; Pancreas specific ras association domain family 1 protein; Ras association domain containing protein 1; Ras association domain family 1; Ras association domain family 1A; Ras association domain family protein 1; Ras association domain-containing protein 1; Ras association RalGDS/AF6 domain family 1; RASF1; RASSF 1; RASSF 1a; RASSF1; RASSF1A; RASSF1A isoform; RDA 32; RDA32; REH3P21; Tumor suppressor protein RDA32;

Immunogen: Recombinant full length Human RASSF1.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: