Rat Anti-Mouse ALK5 Antibody | 103-M96

Rat Anti-Mouse ALK5 Antibody | 103-M96 | Gentaur UK, US & Europe Distribution

Species: Anti-Mouse

Host / biotech: Rat

Comment: N/A

Label: N/A

Clone / Antibody feature: (#3A11)

Subcategory: Monoclonal Antibody

Category: Antibody

Synonyms: Tgfbr1; ALK5; Alk-5; TbetaRI; AU017191; TbetaR-I

Isotype: IgG2

Application: WB, IHC

Detection Range: N/A

Species Reactivity/Cross reactivity: Mouse

Antigen: recmobinant mouse ALK5 extracellular domain

Description: Most cell types express three sizes of receptors for TGFβ. These are designated Type I (53 kDa), Type II (7085 kDa), and Type III (250-350 kDa). The Type III receptor, a proteoglycan that exists in membranebound and soluble forms, binds TGFβ1, TGFβ2, and TGFβ3 but does not appear to be involved in signal transduction. The Type II receptor is a membrane bound serine/threonine kinase that binds TGFβ1 and TGFβ3 with high affinity and TGFβ2 with a much lower affinity. The Type I receptor, originally known as ALK5 (Activin receptor-like kinase) is also a membranebound serine/threonine kinase that apparently requires the presence of the Type II receptor to bind TGFβ. Current evidence suggests that signal transduction requires the cytoplasmic domains of both the Type I and Type II receptors.

Purity Confirmation: N/A

Endotoxin: N/A

Formulation: lyophilized

Storage Handling Stability: Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

Reconstituation: Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

Molecular Weight: N/A

Lenght (aa): N/A

Protein Sequence: N/A

NCBI Gene ID: 21812