Rat Anti-Mouse Frizzled-1 Antibody | 103-M385

Rat Anti-Mouse Frizzled-1 Antibody | 103-M385 | Gentaur UK, US & Europe Distribution

Species: Anti-Mouse

Host / biotech: Rat

Comment: N/A

Label: N/A

Clone / Antibody feature: (#9A12)

Subcategory: Monoclonal Antibody

Category: Antibody

Synonyms: Fzd1; Fz1; FZ-1; AW227548

Isotype: IgG1

Application: WB

Detection Range: N/A

Species Reactivity/Cross reactivity: Mouse

Antigen: recombinant mouse protein Frizzled 1

Description: The Wnt genes encode a large family of glycoproteins that are essential in development and tissue maintenance. Members of the Frizzled family of proteins serve as receptors for the Wnt signaling pathway. Ten mouse and human Frizzled genes have been identified to date. The predicted structure of Frizzled proteins is similar among all family members, containing a divergent N-terminal signal peptide, a highly conserved extracellular cysteine rich domain (CRD), a variablelength linker region, a seven-pass transmembrane region, and a variablelength C-terminal cytoplasmic domain. The CRD, which comprises 642 amino acids and shares 95% identity with the human orthologue in the CRD. Frizzled1 mRNA has been detected in relatively large amounts in adult heart, placenta, lung, kidney, pancreas, prostate, and ovary, and in fetal lung and kidney. Several Frizzled dependent signaling pathways exist. Their activation depends on the Wnt ligand and the cell context. Members of the low density lipoprotein receptorrelated protein (LRP) are coreceptors for the Wnt ligands.

Purity Confirmation: N/A

Endotoxin: N/A

Formulation: lyophilized

Storage Handling Stability: Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

Reconstituation: Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

Molecular Weight: N/A

Lenght (aa): N/A

Protein Sequence: N/A

NCBI Gene ID: 14362