Rat Anti-Mouse Trk-B Antibody | 103-M196

Rat Anti-Mouse Trk-B Antibody | 103-M196 | Gentaur UK, US & Europe Distribution

Species: Anti-Mouse

Host / biotech: Rat

Comment: N/A

Label: N/A

Clone / Antibody feature: (#6B10)

Subcategory: Monoclonal Antibody

Category: Antibody

Synonyms: Ntrk2; Tkrb; trkB; AI848316; C030027L06Rik

Isotype: IgG2

Application: WB, IHC (P)

Detection Range: N/A

Species Reactivity/Cross reactivity: Mouse

Antigen: Recombinant Mouse Trk-B extracellular domain

Description: The neurotrophins, including NGF, BDNF, NT3 and NT4/5, constitute a group of structurally related, secreted proteins that play an important role in the development and function of the nervous system. The biological activities of the neurotrophins are mediated by binding to and activating two unrelated receptor types: the p75 neurotrophin receptor (p75NTR) and the Trk family of receptor tyrosine kinases. p75NTR is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and has been designated TNFRSF16. It binds all neurotrophins with low affinity to transduce cellular signaling pathways that synergize with or antagonize those activated by the Trk receptors. Three Trk family proteins, TrkA, TrkB, and TrkC, exhibiting different ligand specificities, have been identified. TrkA binds NGF and NT3, TrkB binds BDNF, NT3 and NT4/5, and TrkC only binds NT3. All Trk family proteins share a conserved, complex subdomain organization consisting of a signal peptide, two cysteinerich domains, a cluster of three leucinerich motifs, and two immunoglobulinlike domains in the extracellular region, as well as an intracellular region that contains the tyrosine kinase domain. Natural splice variants of the different Trks, lacking the first cysteinerich domain, the first and second or all three of the leucine-rich motifs, or the tyrosine kinase domain, have been described. At the protein sequence level, human and mouse TrkB show 94% amino acid sequence identity. The proteins also exhibit crossspecies activity. The primary location of TrkB expression is in the central and peripheral nervous systems. Low level TrkB expression has also been observed in a wide variety of tissues outside the nervous system.

Purity Confirmation: N/A

Endotoxin: N/A

Formulation: lyophilized

Storage Handling Stability: Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

Reconstituation: Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

Molecular Weight: N/A

Lenght (aa): N/A

Protein Sequence: N/A

NCBI Gene ID: 18212