RB1 monoclonal Antibody | MB64854

RB1 monoclonal Antibody | MB64854 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human, Mouse, Rat

Application: IHC, WB

Application Range: WB 1:500, IHC 1:150

Background: The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]

Storage & Stability: PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Specificity: RB transcriptional corepressor 1

Molecular Weight: 106 kDa (Predicted)

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: OSRC; p105-Rb; pp110; PPP1R130; pRb; RB

Immunogen: Human recombinant protein fragment corresponding to amino acids 309-590 of human RB1 (NP_000312) produced in E.coli.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Pathway: N/A