RB1CC1 Antibody (Center) [APR10918G]

RB1CC1 Antibody (Center) [APR10918G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: M

Specificity: This RB1CC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 489-515 amino acids from the Central region of human RB1CC1.

Cellular Localisation: Nucleus. Cytoplasm. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9ESK9}. Preautophagosomal structure. Lysosome Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane that sequesters a portion of the cytoplasm resulting in the formation of an autophagosome

Molecular Weight: 183091

Clone: Polyclonal

Gene Name: RB1CC1 (HGNC:15574)

Gene ID: 9821

Function: Involved in autophagy (PubMed:21775823) . Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225) . Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity) . Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity) . Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124) . Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity) . Functions as a DNA-binding transcription factor (PubMed:12095676) . Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:14533007) . Plays a crucial role in muscular differentiation (PubMed:12163359) . Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity) .

Summary: Tissue Location: Expression levels correlated closely with those of RB1 in cancer cell lines as well as in various normal human tissues Abundantly expressed in human musculoskeletal and cultured osteosarcoma cells.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: RB1-inducible coiled-coil protein 1, FAK family kinase-interacting protein of 200 kDa, FIP200, RB1CC1, KIAA0203, RBICC