RBBP5 Antibody (C-term) [APR04741G]

RBBP5 Antibody (C-term) [APR04741G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This RBBP5 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 451-485 amino acids from the C-terminal region of human RBBP5.

Cellular Localisation: Nucleus.

Molecular Weight: 59153

Clone: Polyclonal

Gene Name: RBBP5

Gene ID: 5929

Function: In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid (By similarity) . Does not affect ES cell self-renewal (By similarity) . Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters (PubMed:19131338) . As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3 (PubMed:19556245) . Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:19556245) . In association with ASH2L and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:22266653, PubMed:21220120) .

Summary: Tissue Location: Ubiquitously expressed.

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB, IF

Dilution: IF--1:25 WB--1:1000

Synonyms: Retinoblastoma-binding protein 5, RBBP-5, Retinoblastoma-binding protein RBQ-3, RBBP5, RBQ3