RBM39 Antibody (N-term) [APR31201G]

RBM39 Antibody (N-term) [APR31201G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This RBM39 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 114-143 amino acids from the N-terminal region of human RBM39.

Cellular Localisation: Nucleus speckle. Note=Concentrated in nuclear speckles (PubMed:8227358) . Colocalizes with the core spliceosomal snRNP proteins (PubMed:8227358)

Molecular Weight: 59380

Clone: Polyclonal

Gene Name: RBM39 {ECO:0000303|PubMed:28302793, ECO:0000312|HGNC:HGNC:15923}

Gene ID: 9584

Function: RNA-binding protein that acts as a pre-mRNA splicing factor (PubMed:15694343, PubMed:31271494, PubMed:28437394, PubMed:28302793, PubMed:24795046) . Acts by promoting exon inclusion via regulation of exon cassette splicing (PubMed:31271494) . Also acts as a transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1, independently of the pre-mRNA splicing factor activity (By similarity) .

Summary: Tissue Location: Widely expressed. Highly expressed in pancreas, skeletal muscle, lung and brain (PubMed:8227358) . Expressed at intermediate level in kidney, liver and heart (PubMed:8227358)

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: RNA-binding protein 39, CAPER alpha, Hepatocellular carcinoma protein 1, RNA-binding motif protein 39, RNA-binding region-containing protein 2, Splicing factor HCC1, RBM39, HCC1, RNPC2