RCC1Antibody [AMM22127G]

RCC1Antibody [AMM22127G] | Gentaur UK, US & Europe Distribution

Product Category: Monoclonal Antibodies

Host: Mouse

Species Reactivity: H, M

Specificity: This RCC1 monoclonal antibody is generated from mouse immunized with RCC1 recombinant protein.

Cellular Localisation: Nucleus. Chromosome. Cytoplasm Note=Predominantly nuclear in interphase cells (PubMed:12194828) . Binds to mitotic chromosomes (PubMed:12194828, PubMed:17435751, PubMed:20668449) .

Molecular Weight: 44969

Clone: Monoclonal

Gene Name: RCC1

Gene ID: 1104

Function: Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis (PubMed:1944575, PubMed:17435751, PubMed:20668449, PubMed:22215983, PubMed:11336674) . Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis (PubMed:12194828, PubMed:17435751, PubMed:22215983) . Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import (PubMed:22215983) . Involved in the regulation of onset of chromosome condensation in the S phase (PubMed:3678831) . Binds both to the nucleosomes and double- stranded DNA (PubMed:17435751, PubMed:18762580) .

Summary: N/A

Form: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000-1:4000

Synonyms: Regulator of chromosome condensation, Cell cycle regulatory protein, Chromosome condensation protein 1, RCC1, CHC1