Recombinant Human Endothelin-1/ET-1 Protein [E. coli] | 200-017S/200-017

Recombinant Human Endothelin-1/ET-1 Protein [E. coli] | 200-017S/200-017 | Gentaur UK, US & Europe Distribution

Species: Human

Host / biotech: E. coli

Comment: N/A

Label: His-Tag

Clone / Antibody feature: N/A

Subcategory: Cytokines & Growth Factors

Category: Recombinant Protein

Synonyms: Preproendothelin-1, PPET-1, ET-1, EDN1

Isotype: N/A

Application: N/A

Detection Range: N/A

Species Reactivity/Cross reactivity: Human

Antigen: Recombinant Human Endothelin-1

Description: Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor, mainly secreted by endothelial cells. ET-1 acts through two types of receptors: ETA and ETB. Apart from a vasoconstrictive action, ET-1 causes fibrosis of the vascular cells and stimulates production of reactive oxygen species. It is claimed that ET-1 induces proinflammatory mechanisms, increasing superoxide anion production and cytokine secretion. A recent study has shown that ET-1 is involved in the activation of transcription factors such as NF-kappaB and expression of proinflammatory cytokines including TNF-alpha, IL-1, and IL-6. It has been also indicated that during endotoxaemia, the plasma level of ET-1 is increased in various animal species. Some authors indicate a clear correlation between endothelin plasma level and morbidity/mortality rate in septic patients. These pathological effects of ET-1 may be abrogated at least partly by endothelin receptor blockade. ET-1 receptor antagonists may be useful for prevention of various vascular diseases.

Purity Confirmation: > 98% by SDS-PAGE & visualized Coomassie stain

Endotoxin: N/A

Formulation: lyophilized from PBS

Storage Handling Stability: N/A

Reconstituation: N/A

Molecular Weight: 26.0 kDa

Lenght (aa): 204

Protein Sequence: MAPETAVLGA ELSAVGENGG EKPTPSPPWR LRRSKRCSCS SLMDKECVYF CHLDIIWVNT PEHVVPYGLG SPRSKRALEN LLPTKATDRE NRCQCASQKD KKCWNFCQAG KELRAEDIME KDWNNHKKGK DCSKLGKKCI YQQLVRGRKI RRSSEEHLRQ TRSETMRNSV KSSFHDPKLK GKPSRERYVT HNRAHWLEHH HHHH

NCBI Gene ID: 1906