Recombinant Human IL-36 beta (IL-1F8) Protein [E. coli] | 100-091S/100-091

Recombinant Human IL-36 beta (IL-1F8) Protein [E. coli] | 100-091S/100-091 | Gentaur UK, US & Europe Distribution

Species: Human

Host / biotech: E. coli

Comment: N/A

Label: N/A

Clone / Antibody feature: N/A

Subcategory: Cytokines & Growth Factors

Category: Recombinant Protein

Synonyms: FIL1; FIL1H; IL1F8; IL1H2; IL-1F8; IL-1H2; IL1-ETA; FIL1- (ETA); FILI- (ETA)

Isotype: N/A

Application: N/A

Detection Range: Measured by its ability to induce IL-8 production by human PBMCs.

Species Reactivity/Cross reactivity: Human

Antigen: N/A

Description: The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36α (IL-1F6), β (IL-1F8) and γ (IL-1F9). IL-36β is highly expressed in psoriatic plaques, and at lower levels in various other tissues. IL-36β signals through the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells. The interaction of the IL-1Rrp2 receptor with IL-36 ligands induces dendritic cell maturation and activation. IL-36β also functions as an agonist of NF-kappaB, and stimulates the production of pro-inflammatory proteins, including IL-6, IL-8, BD-2, and BD-3. Recombinant human IL-36β is a 17.3 kDa protein containing 154 amino acid residues.

Purity Confirmation: > 98% by SDS-PAGE & HPLC analyses

Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)

Formulation: lyophilized

Storage Handling Stability: N/A

Reconstituation: N/A

Molecular Weight: 17.3 kDa

Lenght (aa): 154

Protein Sequence: MREAAPKSYA IRDSRQMVWV LSGNSLIAAP LSRSIKPVTL HLIACRDTEF SDKEKGNMVY LGIKGKDLCL FCAEIQGKPT LQLKEKNIMD LYVEKKAQKP FLFFHNKEGS TSVFQSVSYP GWFIATSTTS GQPIFLTKER GITNNTNFYL DSVE

NCBI Gene ID: 27177