Recombinant Human TNFSF11 Protein | PH0149E2

Recombinant Human TNFSF11 Protein | PH0149E2 | Gentaur UK, US & Europe Distribution

Short Description: Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy . Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation

Product Type: Cytokine

Form: lyophilized

Purity: Greater than 95% by SDS-PAGE

Storage: -70°C

Buffer: 0.2 μm filtered PBS, pH7.4