209
Recombinant Mouse MIP-1 alpha Protein [E. coli] | M10-035S/M10-035
- SKU:
- 209-M10-035S/209-M10-035-GEN
Description
Recombinant Mouse MIP-1 alpha Protein [E. coli] | M10-035S/M10-035 | Gentaur UK, US & Europe Distribution
Species: Mouse
Host / biotech: E. coli
Comment: N/A
Label: N/A
Clone / Antibody feature: N/A
Subcategory: Cytokines & Growth Factors
Category: Recombinant Protein
Synonyms: Ccl3; Mip1a; Scya3; G0S19-1; AI323804; MIP1- (a); LD78alpha; MIP-1alpha; MIP1-alpha
Isotype: N/A
Application: N/A
Detection Range: Determined by its ability to chemoattract murine balb/c splenocytes using a concentration range of 10.0-100.0 ng/ml.
Species Reactivity/Cross reactivity: Mouse, Monkey, Human
Antigen: N/A
Description: Both MIP-1 α and MIP-1 β are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1 α and MIP-1 β exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1 α selectively attracting CD8+ lymphocytes and MIP-1 β selectively attracting CD4+ lymphocytes. Additionally, MIP-1 α and MIP-1 β have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1 α and MIP-1 β are active on human and murine hematopoietic cells. Recombinant murine MIP-1 α is a 7.8 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.
Purity Confirmation: > 98% by SDS-PAGE & HPLC analysis
Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
Formulation: lyophilized
Storage Handling Stability: N/A
Reconstituation: N/A
Molecular Weight: 7.8 kDa
Lenght (aa): 69
Protein Sequence: APYGADTPTA CCFSYSRKIP RQFIVDYFET SSLCSQPGVI FLTKRNRQIC ADSKETWVQE YITDLELNA
NCBI Gene ID: 20302