Recombinant Mouse Wnt-3a Protein [E. coli] | M30-231S/M30-231

Recombinant Mouse Wnt-3a Protein [E. coli] | M30-231S/M30-231 | Gentaur UK, US & Europe Distribution

Species: Mouse

Host / biotech: E. coli

Comment: N/A

Label: His-Tag

Clone / Antibody feature: N/A

Subcategory: Cytokines & Growth Factors

Category: Recombinant Protein

Synonyms: Wingless-type MMTV (mouse mammary tumor virus) integration site family member 3a

Isotype: N/A

Application: N/A

Detection Range: N/A

Species Reactivity/Cross reactivity: Mouse

Antigen: N/A

Description: Wnt-3a belongs to the Wnt family of signaling proteins that play a key role in maintaining the integrity of embryonic and adult tissues. Expression of Wnt-3a occurs primarily along the dorsal midline across overlapping regions of the Central Nervous System (CNS). Wnt-3a signaling is essential for various morphogenetic events, including embryonic patterning, cell determination, cell proliferation, CNS development, and cytoskeletal formation. Like other members of this family, Wnt-3a contains a highly conserved lipid-modified, cysteine-rich domain that is essential for cell signaling. During a biochemical process called the canonical Wnt pathway, Wnt family members bind to and activate, seven-pass transmembrane receptors of the Frizzled family, ultimately leading to the disruption of β-catenin degradation. Intracellular accumulation of β-catenin increases translocation of the protein into the nucleus, where it binds to TCF/LEF transcription factors to promote gene expression. Lack of Wnt signaling disrupts transcriptional activation of tumor suppressor genes, and has been shown to result in neoplastic transformation, oncogenesis, and human degenerative diseases. Recombinant Murine Wnt-3a is a monomeric glycoprotein containing 334 amino acid residues.

Purity Confirmation: > 85% by SDS-PAGE & Coomassie Stain

Endotoxin: N/A

Formulation: lyophilized

Storage Handling Stability: N/A

Reconstituation: N/A

Molecular Weight: N/A

Lenght (aa): 343

Protein Sequence: MSYPIWWSLA VGPQYSSLST QPILCASIPG LVPKQLRFCR NYVEIMPSVA EGVKAGIQEC QHQFRGRRWN CTTVSNSLAI FGPVLDKATR ESAFVHAIAS AGVAFAVTRS CAEGSAAICG CSSRLQGSPG EGWKWGGCSE DIEFGGMVSR EFADARENRP DARSAMNRHN NEAGRQAIAS HMHLKCKCHG LSGSCEVKTC WWSQPDFRTI GDFLKDKYDS ASEMVVEKHR ESRGWVETLR PRYTYFKVPT ERDLVYYEAS PNFCEPNPET GSFGTRDRTC NVSSHGIDGC DLLCCGRGHN ARTERRREKC HCVFHWCCYV SCQECTRVYD VHTCKLEHHH HHH

NCBI Gene ID: 22416