Regorafenib | 2891

Regorafenib is a multi-kinase inhibitor targeting angiogenic (VEGFR, TIE-2), stromal (PDGFR-β) and oncogenic (RAF, RET and c-KIT) receptor tyrosine kinases, with IC₅₀s of 17, 40 and 69 nM for c-KIT, VEGFR2, B-Raf, respectively. Displays potential antiangiogenic and antineoplastic activities.

Regorafenib is a multi-kinase inhibitor targeting angiogenic (VEGFR, TIE-2), stromal (PDGFR-β) and oncogenic (RAF, RET and c-KIT) receptor tyrosine kinases, with IC₅₀s of 17, 40 and 69 nM for c-KIT, VEGFR2, B-Raf, respectively. Displays potential antiangiogenic and antineoplastic activities.

2891 | Regorafenib DataSheet

Alternate Name/Synonyms: 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-methylpicolinamide; BAY 73-4506

Appearance: Off-white solid

Formulation: N/A

CAS Number: 755037-03-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₁H₁₅ClF₄N₄O₃

Molecular Weight: 482.81

Cell-Permeable?: yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>50 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A multi-kinase inhibitor

MDL Number: N/A

PubChem CID: 11167602

SMILES: CNC(=O)C1=NC=CC(=C1)OC2=CC(=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F)F

InChi: InChI=1S/C21H15ClF4N4O3/c1-27-19(31)18-10-13(6-7-28-18)33-12-3-5-17(16(23)9-12)30-20(32)29-11-2-4-15(22)14(8-11)21(24,25)26/h2-10H,1H3,(H,27,31)(H2,29,30,32)

InChi Key: FNHKPVJBJVTLMP-UHFFFAOYSA-N