Renin Inhibitor | 2084

A non-peptide, direct renin inhibitor (IC50 = 0.6 nM for human renin) and an anti-hypertensive agent. Aliskiren confers neuronal resistance to Aβ toxicity in primary rat cortical cultures.

Renin Inhibitor is a non-peptide, direct renin inhibitor (IC50 = 0.6 nM for human renin) and an anti-hypertensive agent. Aliskiren confers neuronal resistance to Aβ toxicity in primary rat cortical cultures.

2084 | Renin Inhibitor DataSheet

Alternate Name/Synonyms: Aliskiren Hemifumarate; (2S,4S,5S,7S)-N-(2-Carbamoyl-2-methylpropyl)-5-amino-4-hydroxy-2,7-diisopropyl-8-[4-methoxy-3-(3-methoxypropoxy)phenyl]-octanamide hemifumarate

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 173334-58-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₃₀H₅₃N₃O₆ • ½C₄H₄O₄

Molecular Weight: 609.79

Cell-Permeable?: Yes

Purity: ≥98%

Solubilities: DMSO (>100 mg/ml) or H2O (>100 mg/ml)

Handling: Protect from moisture

Country of Origin: USA

Tag Line: A potent renin inhibitor

MDL Number: MFCD10566724

PubChem CID: 9939627

SMILES: CC(C)C(CC1=CC(=C(C=C1)OC)OCCCOC)CC(C(CC(C(C)C)C(=O)NCC(C)(C)C(=O)N)O)N.C(=CC(=O)O)C(=O)O

InChi: InChI=1S/C30H53N3O6.C4H4O4/c1-19(2)22(14-21-10-11-26(38-8)27(15-21)39-13-9-12-37-7)16-24(31)25(34)17-23(20(3)4)28(35)33-18-30(5,6)29(32)36;5-3(6)1-2-4(7)8/h10-11,15,19-20,22-25,34H,9,12-14,16-18,31H2,1-8H3,(H2,32,36)(H,33,35);1-2H,(H,5,6)(H,7,8)/b;2-1+/t22-,23-,24-,25-;/m0./s1

InChi Key: RSFGNDXWVZPKJA-KVBHIGNWSA-N