Reserpine | B2681

Reserpine is an alkaloid isolated from dried roots of R. serpentine. Reserpine irreversibly inhibits both human isoforms of vesicular monoamine transporter, VMAT1 and VMAT2 (Kis = 34 and 12 nM, respectively). It also inhibits adrenaline induced-cutaneous blood vessel constriction and diminishes the effect of hyperthyroidism on cardiovascular and nervous system. Reserpine also inhibits the multidrug resistance protein P-glycoprotein (IC₅₀ = 0.5 µM).

Reserpine is an alkaloid isolated from dried roots of R. serpentine. Reserpine irreversibly inhibits both human isoforms of vesicular monoamine transporter, VMAT1 and VMAT2 (Kis = 34 and 12 nM, respectively). It also inhibits adrenaline induced-cutaneous blood vessel constriction and diminishes the effect of hyperthyroidism on cardiovascular and nervous system. Reserpine also inhibits the multidrug resistance protein P-glycoprotein (IC₅₀ = 0.5 µM).

B2681 | Reserpine DataSheet

Alternate Name/Synonyms: NSC 59272,NSC 237659,(3β,16β,17α,18β,20α)-11,17-dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-yohimban-16-carboxylic acid, methyl ester,Rausedil

Appearance: White to off-white solid

Formulation:

CAS Number: 50-55-5

Structure Available?: TRUE

Peptide sequence: N/A

Salt Form: FALSE

Molecular Formula: C₃₃H₄₀N₂O₉

Molecular Weight: 608.68

Cell-Permeable?: TRUE

Purity: ≥98% by HPLC

Solubilities: ~10 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: Vesicular monoamine transporter inhibitor

MDL Number: MFCD00005091

PubChem CID: 5770

SMILES: COC1C(CC2CN3CCC4=C(C3CC2C1C(=O)OC)NC5=C4C=CC(=C5)OC)OC(=O)C6=CC(=C(C(=C6)OC)OC)OC

InChi: InChI=1S/C33H40N2O9/c1-38-19-7-8-20-21-9-10-35-16-18-13-27(44-32(36)17-11-25(39-2)30(41-4)26(12-17)40-3)31(42-5)28(33(37)43-6)22(18)15-24(35)29(21)34-23(20)14-19/h7-8,11-12,14,18,22,24,27-28,31,34H,9-10,13,15-16H2,1-6H3/t18-,22+,24-,27-,28+,31+/m1/s1

InChi Key: QEVHRUUCFGRFIF-MDEJGZGSSA-N