Retro-2 | 2516

An inhibitor of ribosome-inactivating proteins (RIPs). At a concentration of 200 mg/kg, Retro-2 displayed full protection of mice against a dose of ricin that killed 90% of an unprotected control mouse population. Blocks Leishmania parasitophorous vacuole (LPV) development. Retro-2 inhibited the replication of Leishmania parasites in axenic cultures.

An inhibitor of ribosome-inactivating proteins (RIPs). At a concentration of 200 mg/kg, Retro-2 displayed full protection of mice against a dose of ricin that killed 90% of an unprotected control mouse population

2516 | Retro-2 DataSheet

Alternate Name/Synonyms: Retro-2(cycl); (±)-2-(5-methylthiophen-2-yl)-3-phenyl-2,3-dihydroquinazolin-4(1H)-one; Ricin retrograde transport blocker

Appearance: Off-white solid

Formulation: N/A

CAS Number: 1429192-00-6

Structure Available?: Yes

Peptide sequence: No

Salt Form: No

Molecular Formula: C₁₉H₁₆N₂OS

Molecular Weight: 320.41

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: Inhibitor of Ribosome-Inactivating Proteins (RIPs)

MDL Number: N/A

PubChem CID: N/A

SMILES: O=C1N(C2=CC=CC=C2)C(C3=CC=C(C)S3)NC4=C1C=CC=C4

InChi: InChI=1S/C19H16N2OS/c1-13-11-12-17(23-13)18-20-16-10-6-5-9-15(16)19(22)21(18)14-7-3-2-4-8-14/h2-12,18,20H,1H3

InChi Key: BOAPXDSRULBILC-UHFFFAOYSA-N