RG-7112 | B1919

RG-7112 is a Nutlin imidazoline compound that acts as a potent MDM2 inhibitor as well as displays antineoplastic activity. RG-7112 binds to MDM2, thereby preventing the binding of the MDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53.

RG-7112 is a Nutlin imidazoline compound that acts as a potent MDM2 inhibitor as well as displays antineoplastic activity. RG-7112 binds to MDM2, thereby preventing the binding of the MDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53.

B1919 | RG-7112 DataSheet

Alternate Name/Synonyms: ((4S,5R)-2-(4-(tert-butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethyl-4,5-dihydro-1H-imidazol-1-yl)(4-(3-(methylsulfonyl)propyl)piperazin-1-yl)methanone; RG7112; RO5045337

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 939981-39-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₈H₄₈Cl₂N₄O₄S

Molecular Weight: 727.78

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent MDM2 inhibitor

MDL Number: N/A

PubChem CID: 57406853

SMILES: CCOC1=C(C=CC(=C1)C(C)(C)C)C2=NC(C(N2C(=O)N3CCN(CC3)CCCS(=O)(=O)C)(C)C4=CC=C(C=C4)Cl)(C)C5=CC=C(C=C5)Cl

InChi: InChI=1S/C38H48Cl2N4O4S/c1-8-48-33-26-29(36(2,3)4)14-19-32(33)34-41-37(5,27-10-15-30(39)16-11-27)38(6,28-12-17-31(40)18-13-28)44(34)35(45)43-23-21-42(22-24-43)20-9-25-49(7,46)47/h10-19,26H,8-9,20-25H2,1-7H3/t37-,38+/m0/s1

InChi Key: QBGKPEROWUKSBK-QPPIDDCLSA-N