RGS1 polyclonal Antibody | BS5894

RGS1 polyclonal Antibody | BS5894 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC

Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200

Background: Heterotrimeric G proteins function to relay information from cell surface receptors to intracellular effectors. In mammals, G protein α, β and γ polypeptides are encoded by at least 16, 4 and 7 genes, respectively. Most interest in G proteins has been focused on their α subunits, since these proteins bind and hydrolyze GTP and most obviously regulate the activity of the best studied effectors. Several Gα GTPase activating proteins (GAPs) have been identified and are designated RGS1, RGS2, RGS4, RGS7, RGS9, RGS10 and GAIP (Gα-interacting protein) . Each of these proteins has been shown to deactivate specific Gα isoforms by increasing the rate at which they convert GTP to GDP. RGS2 has been shown to be an inhibitor of Gα q function. RGS9 expression is restricted to photoreceptor cells and RGS9 has been shown to regulate Gα t.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: RGS1 polyclonal Antibody detects endogenous levels of RGS1 protein.

Molecular Weight: ~ 22 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Regulator of G-protein signaling 1; RGS-1; B-cell activation protein BL34; Early response protein 1R20; 1R20; BL34; IER1

Immunogen: Synthetic peptide, corresponding to amino acids 161-206 of Human RGS1.

Conjugate: N/A

Modification: N/A

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: N/A