RGS19 (phospho-S151) polyclonal Antibody | BS64163

RGS19 (phospho-S151) polyclonal Antibody | BS64163 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: Heterotrimeric G proteins function to relay information from cell surface receptors to intracellular effectors. In mammals, G protein α, β and γ polypeptides are encoded by at least 16, 4 and 7 genes, respectively. Most interest in G proteins has been focused on their α subunits, since these proteins bind and hydrolyze GTP and most obviously regulate the activity of the best studied effectors. Four Gα GTPase-activating proteins (GAPs) have been identified and are designated RGS1 (regulator of G protein signaling), RGS4, RGS10 and GAIP (Gα-interacting protein) . Each of these proteins has been shown to deactivate specific Gα isoforms by increasing the rate at which they convert GTP to GDP, RGS1, RGS4 and GAIP bind tightly to and exhibit GAP activity towards Gα i, Gα o and Gα t, but not Gα s. RGS10 increases the GTP hydrolytic activity of several members of the Gα i subfamily including Gα i-3, Gα z and Gα o.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: RGS19 (phospho-S151) polyclonal Antibody detects endogenous levels of RGS19 protein only when phosphorylated at Ser151.

Molecular Weight: ~ 25 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Regulator of G-protein signaling 19; RGS19; G-alpha-interacting protein; GAIP; RGS19; GAIP; GNAI3IP

Immunogen: Synthetic phosphopeptide derived from human RGS19 around the phosphorylation site of Serine 151.

Conjugate: Unconjugated

Modification: Phosphorylation

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: