RGS2 Antibody (N-term) [APR04526G]

RGS2 Antibody (N-term) [APR04526G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This RGS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-32 amino acids from the N-terminal region of human RGS2.

Cellular Localisation: [Isoform 1]: Cell membrane. Cytoplasm. Nucleus, nucleolus [Isoform 3]: Cell membrane. Cytoplasm Nucleus, nucleolus

Molecular Weight: 24382

Clone: Polyclonal

Gene Name: RGS2

Gene ID: 5997

Function: Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP- bound form (PubMed:11063746, PubMed:19478087) . It is involved in the negative regulation of the angiotensin-activated signaling pathway (PubMed:28784619) . Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity) . Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (PubMed:19736320) .

Summary: Tissue Location: Expressed in acute myelogenous leukemia (AML) and in acute lymphoblastic leukemia (ALL) .

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Regulator of G-protein signaling 2, RGS2, Cell growth-inhibiting gene 31 protein, G0/G1 switch regulatory protein 8, RGS2, G0S8