RGS7 Antibody (C-term) [AMM07601G]

RGS7 Antibody (C-term) [AMM07601G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This RGS7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 440-469 amino acids from the C-terminal region of human RGS7.

Cellular Localisation: Cytoplasm, cytosol. Cytoplasm Cell membrane. Membrane; Peripheral membrane protein; Cytoplasmic side. Note=Interaction with PKD1 promotes location at the cell membrane (PubMed:10339594) . Interaction with RGS7BP promotes location at the cell membrane (PubMed:15897264)

Molecular Weight: 57668

Clone: Polyclonal

Gene Name: RGS7

Gene ID: 6000

Function: Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP- bound form (PubMed:10521509, PubMed:10862767) . The RGS7/GNB5 dimer enhances GNAO1 GTPase activity (PubMed:10521509) . May play a role in synaptic vesicle exocytosis (PubMed:12659861) . Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling (PubMed:15897264) .

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P

Dilution: WB--1:1000 IHC-P--1:100~500

Synonyms: Regulator of G-protein signaling 7, RGS7, RGS7