RGS7 polyclonal Antibody | BS8383

RGS7 polyclonal Antibody | BS8383 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB 1:500 - 1:2000

Background: Heterotrimeric G proteins function to relay information from cell surface receptors to various intracellular effectors. G proteins comprise α, β and γ subunits, and following activation the α subunit binds GTP and dissociates from the βγ complex. A large group of proteins have been identified as GTPase-activating proteins (GAPs), including the RGS (regulator of G protein signaling) family, which serve to deactivate specific Gα isoforms by increasing the rate at which they convert GTP to GDP. A subfamily of RGS proteins expressed in the central nervous system contain, in addition to the highly conserved RGS domain, a characteristic GGL domain, or G protein γ subunit-like domain, which mediates binding to Gβ 5 subunits. This subfamily, which includes RGS6, RGS7, RGS9 and RGS11, associates with Gβ 5 to form active GAP complexes that are predominantly localized to the cytosol. RGS/β5 complexes preferentially target Gαo subunit for hydrolysis and inhibit Gβ1γ2-mediated activation of phospholipase C.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: RGS7 polyclonal Antibody detects endogenous levels of RGS7 protein.

Molecular Weight: ~ 58 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Regulator of G-protein signaling 7; RGS7

Immunogen: Recombinant full length Human RGS7.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: